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ea0007p79 | Endocrine tumours and neoplasia | BES2004

Is there an ultra-short loop feedback of ACTH on itself?

Sharma M , Nanzer A , Morris D , Adams E , Korbonits M , Grossman A

It has been postulated that ACTH might modulate its own secretion by a negative feedback loop and we have recently found that the ACTH receptor (MC2R) is present in both normal and tumorous human corticotrophs. In this study we investigated the expression of the ACTH receptor in mouse and rat pituitary tissue as well as mouse pituitary tumour (AtT20) cells and studied the effect of Synacthen (ACTH [1-24]) on ACTH secretion, cAMP release and cell proliferation in AtT20 cells. M...

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ea0089c21 | Clinical – Nuclear Medicine/Interventional Radiology/Imaging | NANETS2022

Characterizing Bone Metastases in Patients with Well-Differentiated Neuroendocrine Neoplasms Utilizing Ga68-DOTATATE PET

Coston, MD Tucker W. , Mahadevia, MBBS Himil J. , Plante, MD Marie M. , Accurso, MD Joseph M. , Sharma, MD, MBA Akash , Johnson, MD, PhD Geoffrey B. , Ashman, MD, PhD Jonathan B. , Tuba Kendi, MD Ayse , Bassam Sonbol, MD Mohamad , Hobday, MD Timothy J. , Halfdanarson, MD Thorvardur R. , Starr, DO Jason S.

Background: Tumors of neuroendocrine origin are a rare, heterogenous group of neoplasms. Neuroendocrine neoplasms (NENs) are categorized by site of origin, differentiation status, and by grade (Ki-67 expression and/or mitotic rate), with significant prognostic variability accordingly. These tumors frequently metastasize to bone, with reported incidence between 6-12% by older SSTR imaging. Our study evaluates patients with well-differentiated tumors of neuroendocrine origin to ...

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Endocrine Abstracts

Is there an ultra-short loop feedback of ACTH on itself?

Characterizing Bone Metastases in Patients with Well-Differentiated Neuroendocrine Neoplasms Utilizing Ga68-DOTATATE PET

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